Diabetes

southernlady

Administrator
Staff member
Hi..

What is wrong with extended release metformin?

Does it have something to do with the DS??
Yes. It has a coating that makes it hard to absorb. Not all extended release affect everyone the same way but with my diabetes, I wasn’t gonna chance it.
 

conceit

Baroness
Liz, so glad you are getting control with only metformin and that it is already dropping.
Thank you for sharing with those of us who had diabetes prior to DS. I understand Marceau in Canada is accumulating 30-year post-op data. In their 20-year data of more than 2,000 patients, they have seen a slight relapse rate over decades in previously diabetic patients (4%), but not a single case of newly developed diabetes after DS. There's a reason for new patients to get the DS before they develop diabetes. Like you said, once it is totally exhausted, the pancreas can only run so long. You have an enlightened doctor. Mine always scolded me, despite my overwhelming family history.

The long term relapse rate of diabetes in those who get the 200+ cm common channel will be something to watch.
It's great to hear Marceau is accumulating 30 year post Op data. Would you have any more information on when this study might be published? I'd be curious to learn the relapse rate at 30 years post Op, as someone getting the surgery at 30. A remission that long would be a dream come true. I am focusing on really preserving beta cell function by strictly low carbing and not taking any meds that make the pancreas secrete more insulin. My A1C fell from 7.1 at diagnosis to 4.9 (slightly artificially lower because of anemia but my meter average was 5.3%), without medication. I am now on the lowest dose of metformin. My fasting stays below 100, seeing 80s and even a few 70s. Post meal numbers are in the 80-110 range 2 hour pp and no higher than 126 1 hour pp. I am very strict with the keto and know that the second I start to go lax, the numbers will creep back up. Glucotoxicity hurts beta cells. So I try to keep numbers close to non D levels, as per Bernstein's recommendations.

I am very interested to see how younger t2ds do over the course of 30, 40 years after surgery. I imagine the relapse rate would likely go up, because insulin sensitivity and beta cell mass go down even in people with no history of diabetes.

I did read the paper on 200 cm cc. Regain was significant. The average A1C for the 200cm group was 5.6, which is really close to pre-d numbers. For the 100 cm group, it was 5.1 The sample size was small though, and it was mentioned that people with the longer cc were generally older. The higher A1C may also be from people having had diabetes for a while, so the A1C might be a tad higher even if still normal. I am very interested in cc lengths, not just for t2d resolution but also concerns surrounding long term malabsorption. I'll probably start a thread about that some time.

Thanks for this post. I didn't know about marceau's study and am excited about it.
 

Munchkin

Full of Fairy Dust
It's great to hear Marceau is accumulating 30 year post Op data. Would you have any more information on when this study might be published? I'd be curious to learn the relapse rate at 30 years post Op, as someone getting the surgery at 30. A remission that long would be a dream come true. I am focusing on really preserving beta cell function by strictly low carbing and not taking any meds that make the pancreas secrete more insulin. My A1C fell from 7.1 at diagnosis to 4.9 (slightly artificially lower because of anemia but my meter average was 5.3%), without medication. I am now on the lowest dose of metformin. My fasting stays below 100, seeing 80s and even a few 70s. Post meal numbers are in the 80-110 range 2 hour pp and no higher than 126 1 hour pp. I am very strict with the keto and know that the second I start to go lax, the numbers will creep back up. Glucotoxicity hurts beta cells. So I try to keep numbers close to non D levels, as per Bernstein's recommendations.

I am very interested to see how younger t2ds do over the course of 30, 40 years after surgery. I imagine the relapse rate would likely go up, because insulin sensitivity and beta cell mass go down even in people with no history of diabetes.

I did read the paper on 200 cm cc. Regain was significant. The average A1C for the 200cm group was 5.6, which is really close to pre-d numbers. For the 100 cm group, it was 5.1 The sample size was small though, and it was mentioned that people with the longer cc were generally older. The higher A1C may also be from people having had diabetes for a while, so the A1C might be a tad higher even if still normal. I am very interested in cc lengths, not just for t2d resolution but also concerns surrounding long term malabsorption. I'll probably start a thread about that some time.

Thanks for this post. I didn't know about marceau's study and am excited about it.
The first article on DS for T2D was authored by a doc named Noyes. The study is still out there somewhere. Sorry, I don't have it. Maybe DianaCox does. His take on it was the best results are with a short CC. I believe he went with 50CM. This study was published in the early 2000's.
 
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