Spiky Bugger we do know, from clinical trials, the short term effects and how substantial the weight loss is for many (not all!) of the participants, that most (not all!) tolerated the drugs pretty well despite the well documented side effects, mostly GI, that tend to improve with time, etc. And I don't recall seeing anything about people developing permanent and severe gastroparesis from these drugs in the clinical trials, though I didn't look for this specifically.
So, I think and hope the numbers for this problem will be small, and that the remarkable benefits for so many people will far outweigh this issue. It is my belief, not yet proven of course, that many people will want to take these meds despite being fully informed of this potential complication, because they are already dealing with all the complications of obesity and have tried everything in their power without success.
I look at this the same way I would consider other drugs. Take penicillin, for example. It has saved countless lives, but some people can't tolerate it due to either allergy or side effects, and some have even died from it due to anaphylaxis. Surely that doesn't mean it's a bad drug. In fact, it's a fantastic drug -- for the right people and the right indications. I believe this will hold true for this new class of drugs as well.
