Soonerjoseph
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A neat article I came across tonight. Folic Acid can be quite bad for you it seems.
http://chriskresser.com/folate-vs-folic-acid/
http://chriskresser.com/folate-vs-folic-acid/
Folate vs Folic Acid
- Thread starter Soonerjoseph
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swimbikerun
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The problem that I see is a lack of science to go along with it. Not all allopathic medicine is garbage science. There is nothing specific in his "studying" and "research" and his resume. I've never seen an L.Ac, and don't know what his masters is in.
I wouldn't necessarily agree that advertising Dr. Oz brought me up is a good thing. He's widely panned for good reasons.
My take is can I prove a true deficiency scientifically and have I taken X that I can show by independent legitimate tests that substance Y fixes/d the deficiency.
I wouldn't necessarily agree that advertising Dr. Oz brought me up is a good thing. He's widely panned for good reasons.
My take is can I prove a true deficiency scientifically and have I taken X that I can show by independent legitimate tests that substance Y fixes/d the deficiency.
I have a PhD in biological chemistry/molecular biology. Your link is mostly bullshit.
https://en.wikipedia.org/wiki/Folic_acid
The difference between folic acid and folate is that folic acid has an extra hydrogen on it - in water, it dissociates to folate (the folic acid without the hydrogen ion).
"Food supplement manufacturers often use the term folate for something different from "pure" folic acid: in chemistry, folate refers to the deprotonated ion, and folic acid to the neutral molecule—which both coexist in water. The International Union of Pure and Applied Chemistry and the International Union of Biochemistry and Molecular Biology state that folate and folic acid are the preferred synonyms for pteroylglutamate and pteroylglutamic acid, respectively.[8]"
https://en.wikipedia.org/wiki/Folic_acid
The difference between folic acid and folate is that folic acid has an extra hydrogen on it - in water, it dissociates to folate (the folic acid without the hydrogen ion).
"Food supplement manufacturers often use the term folate for something different from "pure" folic acid: in chemistry, folate refers to the deprotonated ion, and folic acid to the neutral molecule—which both coexist in water. The International Union of Pure and Applied Chemistry and the International Union of Biochemistry and Molecular Biology state that folate and folic acid are the preferred synonyms for pteroylglutamate and pteroylglutamic acid, respectively.[8]"
Soonerjoseph
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That's good to know! I have a pubmed link that has an interesting abstract but I can't tell what it's really saying without the full article. I guess that Folate is absorbed better under certain PH conditions and the bioavailability isn't effect by metabolic defects. I'd like to find the full article. What do you guys think about it? http://www.ncbi.nlm.nih.gov/pubmed/24494987
Btw, I'm certainly not someone that believes (anything) Dr. Oz or Dr. Mercola or their ilk says.
Btw, I'm certainly not someone that believes (anything) Dr. Oz or Dr. Mercola or their ilk says.
"Naturally occurring 5-MTHF has important advantages over synthetic folic acid - it is well absorbed even when gastrointestinal pH is altered and its bioavailability is not affected by metabolic defects." Comparing apples to oranges - and a misleading statement.
I can't read it either - that's just from the Abstract. But here is a related article that IS available: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095662/
6S-5-methyltetrahydrofolate is a metabolite of folic acid (i.e., it is NOT just the difference between folic acid and folate) - it is already partially processed to its useful form which bypasses the need for the gut to modify folic acid to MTHF.
(I've always giggled at the abbreviated name of the critical enzyme in the pathway methylenetetrahydrafolate reductase: MTHFR. See https://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase)
I can't read it either - that's just from the Abstract. But here is a related article that IS available: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095662/
In conclusion, a low enzyme activity of DHFR may compromise both mucosal and liver biotransformation of folic acid in humans. For dietary supplements, it is suggested that folic acid could be replaced with 6S-5-MTHF (the normal systemically circulating folate form), the multiple advantages of which have been noted previously (32). The Food and Drug Administration in the United States and the European Food Standards Agency have already approved products containing a 5-MTHF calcium salt (Metafolin; Merck & Cie) and a 5-MTHF glucosamine salt (Quatrefolic; Gnosis).
It is also suggested that effort is made to microencapsulate 5-MTHF so that losses from manufacture, the use in voluntary fortified foods (eg, breakfast cereals), and the subsequent processing (eg, heat) of products are minimized (33). If this effort can be accomplished successfully, consideration could be given to replacing folic acid with 5-MTHF in countries that have mandatory programs of flour fortification.
It is also suggested that effort is made to microencapsulate 5-MTHF so that losses from manufacture, the use in voluntary fortified foods (eg, breakfast cereals), and the subsequent processing (eg, heat) of products are minimized (33). If this effort can be accomplished successfully, consideration could be given to replacing folic acid with 5-MTHF in countries that have mandatory programs of flour fortification.
6S-5-methyltetrahydrofolate is a metabolite of folic acid (i.e., it is NOT just the difference between folic acid and folate) - it is already partially processed to its useful form which bypasses the need for the gut to modify folic acid to MTHF.
(I've always giggled at the abbreviated name of the critical enzyme in the pathway methylenetetrahydrafolate reductase: MTHFR. See https://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase)
