Bariatric Surgery Tied to Drop in Uterine Cancer Risk
TAMPA, Fla. -- Obese women who maintained weight loss after bariatric surgery seemed to have a 71% lower risk of developing uterine cancer as compared with women who were obese and did not undergo surgery, investigators reported here.
Overall, obesity almost tripled the risk of uterine cancer as compared with non-obese women. The cancer risk posed by obesity declined sharply in the subgroup of women who had bariatric surgery and remained significantly lower in patients who kept the weight off versus those who did not (RR 0.29, 95% CI 0.27-0.32).
The query produced records for 7,431,858 admissions, including 103,797 patients with a history of bariatric and 44,345 cases of uterine cancer. Investigators separated the patients into currently obese and non-obese groups and further divided them into groups who had a history of bariatric surgery and those who did not.
Overall, non-obese women with a history of bariatric surgery had the lowest risk of uterine cancer at 270/100,000 admissions. Non-obese women without a history of bariatric surgery had the second lowest risk at 496/100,000 admissions.
Among obese patients, those with a history of bariatric surgery had a uterine cancer rate of 682/100,000 admissions, and obese women without a history of bariatric surgery had the highest risk at 1,409/100,000 admissions.
Investigators then calculated the relative risk of uterine cancer as compared with women who were obese and had no history of bariatric procedures. Non-obese women without a history of bariatric surgery had an 81% lower risk (RR 0.19), followed by non-obese women with a history of bariatric surgery (RR 0.29).
Women who were obese despite having undergone bariatric surgery still had 52% lower risk of uterine cancer versus women who were obese and had no history of bariatric procedures (RR 0.48).