Sucalose again, Breaks up DNA.
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hilary1617
First time at the rodeo.
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Yikes. Thanks for sharing!
"For the study, researchers conducted a series of in vitro experiments exposing human blood cells to sucralose-6-acetate and monitoring for markers of genotoxicity."
Huh... I thought red blood cells had no nucleus, hence no DNA... I wonder which of the many white blood cells it altered
Fwiiw.. DNA is always getting screwed up... take a high altitude plane ride and you'll damage DNA... lucky there are nuclear proteins that help correct the errors. That's not to say genotoxic chemicals are good, only that there are recovery mechanisms
Anyone going to give up Splenda based on this report?
For me, it's hard to get perspective.. if you look for things that are genotoxic, lots of stuff comes up, e.g., meat
pubmed.ncbi.nlm.nih.gov
which concludes "The results indicate that diets high in fat and meat but low in dietary fibre increase the genotoxicity of faecal water to colonic cells and may contribute to an enhanced risk of colorectal cancer."
Translation.. eat a lot of meat and your poop is genotoxic
Here's another that I knew about (heterocyclic amines and nitrosamines)
pubmed.ncbi.nlm.nih.gov
"cooking conditions and dietary habits can contribute to human cancer risk through the ingestion of genotoxic compounds from heat-processed foods"
Translation... grill your food and create a genotoxin. You can avoid the problem by boiling instead of grilling meats... but are the carnivores among us going to boil?
My take is splenda is just not necessary, and, with a little effort, you can learn to like bitter coffe.. but beware "Coffee has been shown unequivocally to be genotoxic in vitro"
pubmed.ncbi.nlm.nih.gov
But.. you're in luck but "no genotoxicity has been seen in vivo testing. "
Which goes to show a shortcoming in the splenda study... the results were in vitro, not in vivo
Huh... I thought red blood cells had no nucleus, hence no DNA... I wonder which of the many white blood cells it altered
Fwiiw.. DNA is always getting screwed up... take a high altitude plane ride and you'll damage DNA... lucky there are nuclear proteins that help correct the errors. That's not to say genotoxic chemicals are good, only that there are recovery mechanisms
Anyone going to give up Splenda based on this report?
For me, it's hard to get perspective.. if you look for things that are genotoxic, lots of stuff comes up, e.g., meat
A diet high in fat and meat but low in dietary fibre increases the genotoxic potential of 'faecal water' - PubMed
To determine the effects of different diets on the genotoxicity of human faecal water, a diet rich in fat, meat and sugar but poor in vegetables and free of wholemeal products (diet 1) was consumed by seven healthy volunteers over a period of 12 days. One week after the end of this period, the...
pubmed.ncbi.nlm.nih.gov
which concludes "The results indicate that diets high in fat and meat but low in dietary fibre increase the genotoxicity of faecal water to colonic cells and may contribute to an enhanced risk of colorectal cancer."
Translation.. eat a lot of meat and your poop is genotoxic
Here's another that I knew about (heterocyclic amines and nitrosamines)
Genotoxicity of heat-processed foods - PubMed
Gene-environment interactions include exposure to genotoxic compounds from our diet and it is no doubt, that humans are regularly exposed to e.g. food toxicants, not least from cooked foods. This paper reviews briefly four classes of cooked food toxicants, e.g. acrylamide, heterocyclic amines...
pubmed.ncbi.nlm.nih.gov
"cooking conditions and dietary habits can contribute to human cancer risk through the ingestion of genotoxic compounds from heat-processed foods"
Translation... grill your food and create a genotoxin. You can avoid the problem by boiling instead of grilling meats... but are the carnivores among us going to boil?
My take is splenda is just not necessary, and, with a little effort, you can learn to like bitter coffe.. but beware "Coffee has been shown unequivocally to be genotoxic in vitro"
Analysis of hydrogen peroxide in freshly prepared coffees - PubMed
Coffee has been shown unequivocally to be genotoxic in vitro, but no genotoxicity has been seen in vivo testing. Since the in vitro genotoxicity appears to be dependent on hydrogen peroxide, it is important to know whether hydrogen peroxide is present in prepared coffee and whether it is being...
pubmed.ncbi.nlm.nih.gov
But.. you're in luck but "no genotoxicity has been seen in vivo testing. "
Which goes to show a shortcoming in the splenda study... the results were in vitro, not in vivo
Last edited:
Spiky Bugger
Well-Known Member
- Joined
- Jan 5, 2014
- Messages
- 6,311
"For the study, researchers conducted a series of in vitro experiments exposing human blood cells to sucralose-6-acetate and monitoring for markers of genotoxicity."
Huh... I thought red blood cells had no nucleus, hence no DNA... I wonder which of the many white blood cells it altered
Fwiiw.. DNA is always getting screwed up... take a high altitude plane ride and you'll damage DNA... lucky there are nuclear proteins that help correct the errors. That's not to say genotoxic chemicals are good, only that there are recovery mechanisms
Anyone going to give up Splenda based on this report?
For me, it's hard to get perspective.. if you look for things that are genotoxic, lots of stuff comes up, e.g., meat
A diet high in fat and meat but low in dietary fibre increases the genotoxic potential of 'faecal water' - PubMed
To determine the effects of different diets on the genotoxicity of human faecal water, a diet rich in fat, meat and sugar but poor in vegetables and free of wholemeal products (diet 1) was consumed by seven healthy volunteers over a period of 12 days. One week after the end of this period, the...
which concludes "The results indicate that diets high in fat and meat but low in dietary fibre increase the genotoxicity of faecal water to colonic cells and may contribute to an enhanced risk of colorectal cancer."
Translation.. eat a lot of meat and your poop is genotoxic
Here's another that I knew about (heterocyclic amines and nitrosamines)
Genotoxicity of heat-processed foods - PubMed
Gene-environment interactions include exposure to genotoxic compounds from our diet and it is no doubt, that humans are regularly exposed to e.g. food toxicants, not least from cooked foods. This paper reviews briefly four classes of cooked food toxicants, e.g. acrylamide, heterocyclic amines...
"cooking conditions and dietary habits can contribute to human cancer risk through the ingestion of genotoxic compounds from heat-processed foods"
Translation... grill your food and create a genotoxin. You can avoid the problem by boiling instead of grilling meats... but are the carnivores among us going to boil?
My take is splenda is just not necessary, and, with a little effort, you can learn to like bitter coffe.. but beware "Coffee has been shown unequivocally to be genotoxic in vitro"
Analysis of hydrogen peroxide in freshly prepared coffees - PubMed
Coffee has been shown unequivocally to be genotoxic in vitro, but no genotoxicity has been seen in vivo testing. Since the in vitro genotoxicity appears to be dependent on hydrogen peroxide, it is important to know whether hydrogen peroxide is present in prepared coffee and whether it is being...
But.. you're in luck but "no genotoxicity has been seen in vivo testing. "
Which goes to show a shortcoming in the splenda study... the results were in vitro, not in vivo
I eat some newfangled thing called sugar.
My labs are good and I weight just about half what I did in 2005.
hilary1617
First time at the rodeo.
- Joined
- Jan 6, 2014
- Messages
- 3,870
I'm trying to switch fully to sugar and honey, but still often take Equal in my coffee and like to have a few Frescas a week.
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