Interesting oral iron supplementation research

dahlia123

Member
I had a consult with a hematologist a few weeks ago regarding my iron deficiency. During our appointment, she referenced some relatively recent iron supplementation research that I had not heard about. The doctor explained that they are finding when people take a large dose of oral iron, the body releases its iron regulator hormone helpcidin, which basically stops the body from absorbing any more oral iron for the next 48 hours. They are hypothesizing that it might be more effective for people to supplement with a single, large iron oral dose every other day instead of taking smaller doses multiple times a day. Journal article from The Lancet here.

She said there are few more studies researching this in the works with IDA patients. Sorry if this was already posted- I tried to search but didn’t see anything. I thought it was notable, and am interested to see what future research shows.
 

JackieOnLine

Moderator
Staff member
They are hypothesizing that it might be more effective for people to supplement with a single, large iron oral dose every other day instead of taking smaller doses multiple times a day
I wonder how large.
my doctor is having me supplement 3 times a week.
 

Georgepds

Well-Known Member
Study 1---60 mg each day / 60 mg every other day

Study 2-- 120 mg each day/ 60 each day x2

"study 1, women were randomly assigned (1:1) to two groups. One group was given 60 mg iron at 0800 h (±1 h) on consecutive days for 14 days, and the other group was given the same doses on alternate days for 28 days. In study 2, women were assigned to two groups, stratified by serum ferritin so that two groups with similar iron statuses could be formed. One group was given 120 mg iron at 0800 h (±1 h) and the other was given the dose split into two divided doses of 60 mg at 0800 h (±1 h) and 1700 h (±1 h) for three consecutive days. "
 

RainCity

Well-Known Member
Interesting. I currently take 1 Heme iron pill 1x day after not taking any for awhile and seeing my Ferritin drop to 30 in Sep 2019 versus 65 in May 2018. I wonder if taking 2 pills every other day would be beneficial for me?
Note that I am post-menopausal.
 

Georgepds

Well-Known Member
The syudy was done with iron salts... I dont know enough biochem to say if the same would hold for heme iron,,, after all.. the whole point of heme iron is it has a different absorption path... one that does not compete with calcium absorption
 

southernlady

Administrator
Staff member
The only issue with studies like this is they are done with normal folks, not those of us with malabsorption.

A vast majority of us usually end up on iron infusions (think large dose), that lasts for anywhere from 6 months to several years. In 9 years, I’ve had two infusions. Oral iron is useless for me.
 

Sheanie

Well-Known Member
The study was not done with heme iron. My labs prove that I absorb heme iron very well. I keep my iron infusions 3 to 5 years apart with oral heme.

This study does NOT apply to us. We are zebras in a herd of horses.
 
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