Low Folate, high Ferritin and high MCV

Discussion in 'Vitamins & Labs' started by ginger, Apr 11, 2018.

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    ginger

    ginger Well-Known Member

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    So if your Folate was low which one did you order to supplement ? It's never been this low at 5. in the past it's been borderline. My MCV is high, which tells me Folate is low. However, now my Ferritin is high a 377, with lab high end being 307, normally it's run in the mid 200's. I am 5 yrs post revision, and 15 yrs past original botched DS

    As i caught up on my charting of labs today I finally paid attention to the high MCV as it's been on the high end for several years. I should of not gotten behind !

    I noticed puritan pride makes a tablet Folate https://www.puritan.com/vitamin-b-026/folic-acid-400-mcg-001403 Anyone use it ? with success
    Thanks
     
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    Settledownnow

    Settledownnow Well-Known Member

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    I use this one

    At one time I researched it and I believe you want methyl folate rather than folic acid.

    I took 2 capsules (800 mcg). It raised my folate pretty quickly (by the end of the second bottle). I only take one capsule two days a week now and my folate has been stable.
     
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    DianaCox

    DianaCox Bad Cop

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    One concern: https://www.ncbi.nlm.nih.gov/pubmed/24549403

    Metallomics. 2014 Apr;6(4):748-73. doi: 10.1039/c3mt00347g.
    Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells.
    Kell DB1, Pretorius E.
    Author information

    Abstract
    "Serum ferritin" presents a paradox, as the iron storage protein ferritin is not synthesised in serum yet is to be found there. Serum ferritin is also a well known inflammatory marker, but it is unclear whether serum ferritin reflects or causes inflammation, or whether it is involved in an inflammatory cycle. We argue here that serum ferritin arises from damaged cells, and is thus a marker of cellular damage. The protein in serum ferritin is considered benign, but it has lost (i.e. dumped) most of its normal complement of iron which when unliganded is highly toxic. The facts that serum ferritin levels can correlate with both disease and with body iron stores are thus expected on simple chemical kinetic grounds. Serum ferritin levels also correlate with other phenotypic readouts such as erythrocyte morphology. Overall, this systems approach serves to explain a number of apparent paradoxes of serum ferritin, including (i) why it correlates with biomarkers of cell damage, (ii) why it correlates with biomarkers of hydroxyl radical formation (and oxidative stress) and (iii) therefore why it correlates with the presence and/or severity of numerous diseases. This leads to suggestions for how one might exploit the corollaries of the recognition that serum ferritin levels mainly represent a consequence of cell stress and damage.
     

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