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Liver function tests abnormal

Discussion in 'Duodenal Switch' started by DianaCox, Jan 16, 2017.

  1.  
    DianaCox

    DianaCox Bad Cop

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    OK, this is strange - I had my LFTs redrawn two days ago when I had some missing tests from my annual labs done (Vit K, ferritin and CRP were missed). And look at my numbers now! I have bought but not started taking the Vit E and Coromega (I'm redoing my 4 weeks of pills tomorrow, when I will add them):

    Date ..... AST (0-40) ... ALT (0-32) Comments
    1/9/17 .. 136 ............... 162 ........... Initial appointment

    1/27/17 . 126 .............. 274 ........... Recheck

    2/20/17 .. 74 ............... 145 ........... After stopping Vit A, D, K1, K2

    5/18/17 .. 48 ............... 184 ........... After resuming ½ dose of Vit A, D, K1, K2

    8/10/17 . 237 ............. 249 .......... Still taking 1/2 doses of vites.

    9/13/17 .. 28 ................ 59 .......... I didn't change ANYTHING - AST NORMAL! ALT barely above normal!

    And my ferritin was 152 - top of the range is 150 - I haven't had an infusion for 2.5 years. My CRP was very normal too.

    I'm not complaining - just confused!
     
    Spiky Bugger likes this.
  2.  
    hilary1617

    hilary1617 First time at the rodeo.

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    @DianaCox What!?! Well, that's just awesome!
     
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  3.  
    DianaCox

    DianaCox Bad Cop

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    Latest updated levels - the liver doc said they were good enough that he canceled my upcoming appointment. I added vitamin E but never took any of the Coromega.


    Date ..... AST (0-40) ... ALT (0-32) Comments
    1/9/17 .. 136 ............... 162 ........... Initial appointment

    1/27/17 . 126 .............. 274 ........... Recheck

    2/20/17 .. 74 ............... 145 ........... After stopping Vit A, D, K1, K2

    5/18/17 .. 48 ............... 184 ........... After resuming ½ dose of Vit A, D, K1, K2

    8/10/17 . 237 ............. 249 .......... Still taking 1/2 doses of vites.

    9/13/17 .. 28 ................ 59 .......... I didn't change ANYTHING - AST NORMAL! ALT barely above normal!

    11/28/17 . 75 ................ 96 ......... High, but not alarmingly so



    These are the numbers overall (including additional tests) which I copied from the annoyingly graphic-intense LabCorp site:
    Albumin, Serum
    4.1 NORMAL

    Reference Range: 3.6-4.8 g/dL

    Alkaline Phosphatase, S
    105 NORMAL

    Reference Range: 39-117 IU/L

    AST (SGOT)
    75 HIGH

    Reference Range: 0-40 IU/L

    Bilirubin, Total/Direct, Serum
    0.9 NORMAL

    Reference Range: 0.0-1.2 mg/dL

    Bilirubin, Direct
    0.24 NORMAL

    Reference Range: 0.00-0.40 mg/dL

    Bilirubin, Indirect
    0.66 NORMAL

    Reference Range: 0.10-0.80 mg/dL

    ALT (SGPT)
    96 HIGH

    Reference Range: 0-32 IU/L

    Vitamin A, Serum
    71 NORMAL

    Reference Range: 26-82 ug/dL

    Vitamin D, 25-Hydroxy, Total
    Vitamin D, 25-Hydroxy, Serum
    76 NORMAL

    Reference Range: All Ages: Target levels 30 - 100
     
  4.  
    DianaCox

    DianaCox Bad Cop

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    Another update. Five or so months ago, when my numbers were high, my liver doc suggested a consult with Banner Hospital in Phoenix, which is running clinical trials on drugs for liver fibrosis, which I presumably have due to NAFLD. The appointment finally occurred today. I had a fibroscan, and the number came back in the "not-that-bad-but-something-to-keep-an-eye-on" category of stage 2. https://www.racgp.org.au/afp/2013/july/fibroscan/ My fibroscan score was 7.8.

    So the interesting thing was that there were 2 clinical trials for drugs for fibrosis, but one you had to have a score of stage 3, and the other took stage 2 but no history of bariatric surgery allowed. So I didn't qualify for either.

    The doctor suggested that I could have a liver biopsy for a definitive answer (more likely than not, the biopsy would show LESS fibrosis than the fibroscan, because it tends to overestimate in older people and heavier people - I'm not that heavy now, but ...) - so the bottom line was, if I had a biopsy, which is a painful procedure, NOTHING about my treatment would likely change. So, no thanks.

    Interesting that these drugs are in phase 3 though - note to @DSRIGGS .
     
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  5.  
    Clematis

    Clematis Well-Known Member

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    After elevated liver tests and fat blobs visible on a scan (NAFLD), my doc just had me start taking OTC Silymarin (Milk Thistle) 200mg twice a day. She said one of her med school mentors ran studies on it and found it to be beneficial for those with NAFLD. She says she has had great success with her own patients and it works fast - one can see if it's working with a liver panel 6 weeks later. I'll get blood work in 4 weeks and let you know.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612568/

    Not scientific but the first place I've seen reference rapid weight loss as cause for NAFLD. https://www.drweil.com/health-wellness/body-mind-spirit/liver-kidney/fighting-fatty-liver/
     
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  6.  
    DSRIGGS

    DSRIGGS Yes, that is chocolate covered bacon

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    Thanks Diana. My GI who is a liver specialist as well ran numerous tests on me and since my liver function is very good he said that I should just watch how much I drink (okay he actually said I shouldn't drink at all but I have a glass of with dinner maybe once a week). As he said I am lucky in that although I am in stage 3 which is irreversible, but it hasn't hurt my function to this point. Basically he would have told me to lose weight and get my Diabetes under control. My one big positive from my DS struggles is that I am no long a T2DM patient and I have a normal BMI. That being said I will keep an eye on these drug trials as I might be needing them someday.
     
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